American Idioms – Idiom Wizard Lists Over 5,500 Idioms & Slang Descriptions

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Set up shop

Start a permanent project. Find a place and occupy it for  one’s  work area. ‘Shop’ is used in the sense of a work space, so set  up shop is to begin a store, business or hobby.

“I see that same homeless guy on the street corner asking for money, he has set up shop in the busiest intersection in town.”

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